Combination of Resveratrol and Quercetin Causes Cell Growth Inhibition, DNA Damage, Cell Cycle Arrest, and Apoptosis in Oral Cancer Cells.

@article{Singh2020CombinationOR,
  title={Combination of Resveratrol and Quercetin Causes Cell Growth Inhibition, DNA Damage, Cell Cycle Arrest, and Apoptosis in Oral Cancer Cells.},
  author={Virendra Singh and Ragini D Singh and Praveen Kumar Kujur and Rana Pratap Singh},
  journal={Assay and drug development technologies},
  year={2020}
}
Resveratrol and quercetin alone are well reported to have anticancer potential, but their combination studies are very inadequate. We have examined their combination in Cal-33 and SCC-15 oral cancer cells (OCCs) and noncancerous HEK-293 cells. Combination of 10 μM concentration of each resveratrol and quercetin brought additive effect on cellular growth, DNA damage, S-phase cell cycle arrest, and cell death in Cal-33 cells but not in the HEK-293 cells. Augmentation of the cell cycle regulatory… 
Application of Quercetin in the Treatment of Gastrointestinal Cancers
TLDR
The therapeutic effects of quercetin in gastrointestinal cancers (pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral) are summarized.
Resveratrol effects in oral cancer cells: a comprehensive review
TLDR
This review discusses the different action mechanisms of resveratrol related in the in vitro and in vivo studies using models of oral cancer.
Effects and mechanisms of resveratrol for prevention and management of cancers: An updated review.
TLDR
The effects and mechanisms of resveratrol on different cancers are summarized and crude extract containing resver atrol is developed into functional food, dietary supplements or auxiliary agents for prevention and management of cancers.
Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis
TLDR
The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.
Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling
TLDR
It is suggested that the development of improved target-specific personalized therapies can combat HNC’s global plight by targeting the potential biomarkers in light of new molecular targeted therapies.
Fruit and vegetable consumption and incident breast cancer: a systematic review and meta-analysis of prospective studies.
TLDR
It is suggested that high total fruit and vegetable consumption are associated with reduced risk of overall, postmenopausal, ER+/PR+ and ER-/PR- breast cancer.

References

SHOWING 1-10 OF 26 REFERENCES
Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines.
TLDR
It is suggested that resveratrol exerts chemopreventive effects on colonic cancer cells by inhibition of the cell cycle.
Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells.
TLDR
It is suggested that resveratrol can induce apoptotic cell death in human leukemic cells to a greater extent than in human solid tumor cells via reducing Akt activation due to Ras downregulation.
Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis
TLDR
It is found that quercetin interacts with DNA directly, and could be one of the mechanisms for inducing apoptosis in both, cancer cell lines and tumor tissues by activating the intrinsic pathway.
Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation.
TLDR
It is concluded that resveratrol or a combination of resver atrol and quercetin, in concentrations equivalent to that present in red wines, are effective inhibitors of oral squamous carcinoma cell (SCC-25) growth and proliferation, and warrant further investigation as cancer chemopreventive agents.
Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling.
TLDR
The findings indicate that resveratrol is likely to induce autophagic and apoptotic death in drug-resistant oral cancer cells and might become a new approach for oral cancer treatment in the near future.
Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas
TLDR
Combinations of CUR and RES was more effective in inhibiting in vivo and in vitro cancer growth than the treatment with CUR.
Inhibition of gastric cancer cell proliferation by resveratrol: role of nitric oxide.
TLDR
The results revealed that the antioxidant action of resveratrol toward gastric adenocarcinoma SNU-1 cells may reside in its ability to stimulate NOS to produce low levels of NO, which, in turn, exert antioxidant action.
...
...