Combination of Matrine and Sorafenib Decreases the Aggressive Phenotypes of Hepatocellular Carcinoma Cells.

@article{Lin2014CombinationOM,
  title={Combination of Matrine and Sorafenib Decreases the Aggressive Phenotypes of Hepatocellular Carcinoma Cells.},
  author={Yan Lin and Lian-jie Lin and Yu Jin and Dongxu Wang and Yue Tan and Changqing Zheng},
  journal={Chemotherapy},
  year={2014},
  volume={60 2},
  pages={112-8}
}
BACKGROUND The aim of this study was to determine the effects of matrine (a natural alkaloid) on sorafenib-induced cytotoxicity against hepatocellular carcinoma (HCC) cells, and to explore the molecular mechanisms involved. METHODS HepG2 and Hep3B cells were treated with matrine alone or in combination with sorafenib, and cell viability and apoptosis were assessed. The involvement of micro (mi)RNA-21 in the action of matrine was examined. RESULTS Matrine significantly augmented the… CONTINUE READING