Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice.

@article{David2016CombinationOM,
  title={Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice.},
  author={Bruna Ara{\'u}jo David and Rafael Machado Rezende and Ma{\'i}sa Mota Antunes and M{\^o}nica Morais Santos and Maria Alice Freitas Lopes and Ariane Barros Diniz and Rafaela Vaz Sousa Pereira and Sarah Cozzer Marchesi and Debora M Alvarenga and Brenda Naemi Nakagaki and Alan Moreira de Araujo and Daniela Silva Dos Reis and Renata Monti Rocha and Pedro Elias Marques and Woo-Yong Lee and Justin F. Deniset and Pei Xiong Liew and Stephen J. Rubino and Laura M. Cox and Vanessa Pinho and Thiago M Cunha and Gabriel da Rocha Fernandes and Andr{\'e} Gustavo Fernandes Oliveira and Mauro M Teixeira and Paul Kubes and Gustavo Batista Menezes},
  journal={Gastroenterology},
  year={2016},
  volume={151 6},
  pages={1176-1191}
}
BACKGROUND & AIMS Resident macrophages are derived from yolk sac precursors and seed the liver during embryogenesis. Native cells may be replaced by bone marrow precursors during extensive injuries, irradiation, and infections. We investigated the liver populations of myeloid immune cells and their location, as well as the dynamics of phagocyte repopulation after full depletion. The effects on liver function due to the substitution of original phagocytes by bone marrow-derived surrogates were… CONTINUE READING
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