Combination of Imatinib with CXCR 4 antagonist BKT 140 overcomes the protective effect of stroma and targets CML in vitro and in vivo

@inproceedings{Beider2013CombinationOI,
  title={Combination of Imatinib with CXCR 4 antagonist BKT 140 overcomes the protective effect of stroma and targets CML in vitro and in vivo},
  author={Katia Beider and Merav Darash-Yahana and Orly Blaier and Maya Koren-Michowitz and Michal Abraham and H. Wald and Ori Wald and Eithan Galun and Orly Eizenberg and Amnon Peled and Arnon Nagler},
  year={2013}
}
Functional role of CXCR4 in CML progression was evaluated. Elevated CXCR4 significantly increased the in vitro survival and proliferation in response to CXCL12. CXCR4 stimulation resulted in activation of Erk1/2, Akt, S6K, STAT3 and STAT5 pro-survival signaling pathways. In accordance, we found that in vitro treatment with CXCR4 antagonist BKT140 directly inhibited the cell growth and induced cell death of CML cells. Combination of BKT140 with sub-optimal concentrations of imatinib… CONTINUE READING
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CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

  • A Greenbaum, YM Hsu, RB Day, LG Schuettpelz, MJ Christopher, JN Borgerding
  • Nature
  • 2013
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