Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells.

@article{Watts2010CombinationOH,
  title={Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells.},
  author={Korashon Lynn Watts and Colleen R. Delaney and Richard Keith Humphries and Irwin D Bernstein and Hans-Peter Kiem},
  journal={Blood},
  year={2010},
  volume={116 26},
  pages={5859-66}
}
Umbilical cord blood (UCB) is an attractive cell source for hematopoietic cell transplantation (HCT). Here we examine whether the combination of homeobox B4 (HOXB4) and Delta-1 ligand (DL) synergize when used together. Monkey and human UCB CD34(+) cells were transduced with a HOXB4-expressing gammaretroviral vector and cultured with DL. Individual and combined effects of HOXB4 and DL were assessed by colony-forming unit assays, flow cytometry, and nonobese diabetic/severe combined immune… CONTINUE READING

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