Combination of Calcium Channel Blockers and Beta Blockers for Patients with Exercise-Induced Angina Pectoris: A Double-Blind Parallel-Group Comparison of Different Classes of Calcium Channel Blockers

@article{vanderVring1999CombinationOC,
  title={Combination of Calcium Channel Blockers and Beta Blockers for Patients with Exercise-Induced Angina Pectoris: A Double-Blind Parallel-Group Comparison of Different Classes of Calcium Channel Blockers},
  author={J A van der Vring and M. C. Dani{\"e}ls and N. J. Holwerda and P.J.A.M. Withagen and Adri Schelling and Tom JM Cleophas and M.G.C. Hendriks},
  journal={Angiology},
  year={1999},
  volume={50},
  pages={447 - 454}
}
The combination of calcium channel blockers and beta blockers is more effective for the treatment of exercise-induced angina pectoris than beta blocker monotherapy. Since ischemia in exercise-induced angina is essentially preceded by an increase in heart rate, calcium channel blockers with negative chronotropic property may perform better for this purpose than nonchronotropic compounds. A 335-patient, 10-week, double-blind, parallel-group comparison of amlodipine 5 and 10 mg, diltiazem XR 200… 

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References

SHOWING 1-10 OF 15 REFERENCES

Amlodipine combined with beta blockade for chronic angina: Results of a multicenter, placebo‐controlled, randomized double‐blind study

TLDR
The results of this controlled, large‐scale multicenter trial suggest that amlodipine significantly increased exercise capacity and was well tolerated when added to the antianginal regimen of patients remaining symptomatic while receiving beta‐blocking agents.

The Total Ischaemic Burden European Trial (TIBET). Effects of atenolol, nifedipine SR and their combination on the exercise test and the total ischaemic burden in 608 patients with stable angina. The TIBET Study Group.

TLDR
In the management of mild chronic stable angina there appears to be little advantage gained from using combination therapy for ischaemia reduction, according to a multinational study involving 608 patients from 69 centres in nine countries.