Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect

@inproceedings{Mazor2010CombinationOA,
  title={Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect},
  author={Ohad Mazor and Einat Ben-Arie and Adva Mechaly and Ronit Rosenfeld and Hadar Marcus and Arie Ordentlich},
  year={2010}
}
In order to mimic the neutralizing potency of polyclonal antibodies, combinations of neutralizing monoclonal antibodies (mAbs) are used. The main pre-requisite of any preparation which is comprised of several neutralizing mAb is that its antibodies will target distinct epitopes on the antigen molecule. The aim of this study was to elucidate a mixture of antibodies that exhibits a synergistic protective-antigen (PA)-neutralizing activity. We have previously demonstrated that mab29 has a potent… CONTINUE READING