Combination of Active Components Enhances the Efficacy of Prunella in Prevention and Treatment of Lung Cancer

@article{Feng2010CombinationOA,
  title={Combination of Active Components Enhances the Efficacy of Prunella in Prevention and Treatment of Lung Cancer},
  author={Liang Feng and Xiao-Bin Jia and Jun Jiang and Mao-Mao Zhu and Yan Chen and Xiao-bin Tan and Feng Shi},
  journal={Molecules},
  year={2010},
  volume={15},
  pages={7893 - 7906}
}
The efficacy of Prunella extracts in the prevention and treatment of lung cancer has been attributed to different components. In this study, an "active components combination model" hypothesis was proposed to explain the anti-tumor activity of Prunella. The efficacy of Prunella extracts from different regions was compared in vitro and in vivo, and the TNF-α activity in serum of tumor-bearing mice was also evaluated. High performance liquid chromatography (HPLC) was used to analyze the extracts… Expand
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References

SHOWING 1-10 OF 28 REFERENCES
Identification of Two Polysaccharides from Prunella vulgaris L. and Evaluation on Their Anti-Lung Adenocarcinoma Activity
TLDR
Results showed that polysaccharides of PV had anti-lung cancer activity and could increase the thymus index and the spleen index in tumor-bearing mice, suggesting possible immunomodulation effects. Expand
Biological activities of Prunella vulgaris extract
The organic fraction (OF; 25.7% w/w of rosmarinic acid) of Prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (DPPH),Expand
Antimutagenic activity of extracts from anticancer drugs in Chinese medicine.
The antimutagenic activities of extracts of 36 commonly used anticancer crude drugs from Chinese herbs were studied by using the Salmonella/microsomal system in the presence of picrolonic acid orExpand
Immunostimulatory activity of aqueous extract isolated from Prunella vulgaris.
  • E. Han, J. Choi, +5 authors H. Jeong
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2009
TLDR
It is found that PVAE stimulated macrophage phagocytic activity, nitric oxide production and cytostatic activity, and induced gene expression and production ofmacrophage-related cytokines such as TNF-alpha, IL-1beta and IL-6. Expand
Progression from Chronic Atrophic Gastritis to Gastric Cancer; Tangle, Toggle, Tackle with Korea Red Ginseng
TLDR
The possibilities for cancer prevention by controlling inflammation process in Helicobacter pylori-associated inflamed stomach with Korea red ginseng are discussed. Expand
Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil
TLDR
The essential oil of Rhododendron anthopogon was investigated by GC-MS, and seventeen compounds (representing approximately 98% of the oil) were identified; a weak topical anti-inflammatory activity and a significant killing effect against some Gram-positive reference strains were revealed. Expand
Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract.
TLDR
The Ginkgo biloba extract EGb761 was tested for its ability to inhibit the major human cytochrome P450 enzymes (CYPs) and was found to strongly inhibit CYP2C9 and to a lesser extent, CYP1A2. Expand
Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes.
TLDR
The results suggest that P. vulgaris and RA, used in skin care cosmetics, may offer protection against UVA-induced oxidative stress and may be beneficial as a supplement in photoprotective dermatological preparations. Expand
Enhanced analysis of triterpenes, flavonoids and phenolic compounds in Prunella vulgaris L. by capillary zone electrophoresis with the addition of running buffer modifiers.
TLDR
The results reveal that only the isomeric compounds and rosmarinic acid could be detected in the spikes of P. vulgaris L. and its beverage drink products; other components were either too low to be detected or not present while only ros marinic acid was detected inThe beverage products. Expand
Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice.
TLDR
Results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer. Expand
...
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2
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