Combination intrathecal therapy for meningeal leukemia: two versus three drugs.

@article{Sullivan1977CombinationIT,
  title={Combination intrathecal therapy for meningeal leukemia: two versus three drugs.},
  author={Margaret P. Sullivan and Thomas E. Moon and Robert C. Trueworthy and Teresa J. Vietti and Greer B. Humphrey and Diane M Komp},
  journal={Blood},
  year={1977},
  volume={50 3},
  pages={
          471-9
        }
}
The comparative effectiveness of intrathecal (IT) combination chemotherapy using two agents, methotrexate (MTX) and hydrocortisone (HDC), and three agents, MTX, HDC, and cytosine arabinoside (CA), in treating meningeal leukemia was determined in a randomized Southwest Oncology Group study. Following central nervous system (CNS) remission induction the same regimen was used for periodic maintenance until CNS relapse supervened. Complete CNS remission was achieved in 100% of 43 children given two… CONTINUE READING

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