Combination interventions for Hepatitis C and Cirrhosis reduction among people who inject drugs: An agent-based, networked population simulation experiment

@article{Khan2018CombinationIF,
  title={Combination interventions for Hepatitis C and Cirrhosis reduction among people who inject drugs: An agent-based, networked population simulation experiment},
  author={Bilal Khan and Ian Duncan and Mohamed Saad and D. Schaefer and Ashly E. Jordan and Daniel J Smith and Alan Neaigus and Don Des Jarlais and Holly Hagan and Kirk Dombrowski},
  journal={PLoS ONE},
  year={2018},
  volume={13}
}
Hepatitis C virus (HCV) infection is endemic in people who inject drugs (PWID), with prevalence estimates above 60% for PWID in the United States. Previous modeling studies suggest that direct acting antiviral (DAA) treatment can lower overall prevalence in this population, but treatment is often delayed until the onset of advanced liver disease (fibrosis stage 3 or later) due to cost. Lower cost interventions featuring syringe access (SA) and medically assisted treatment (MAT) have shown mixed… 
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24 Citations
Background Citations
3
Results Citations
1

24 Citations

Cost-effectiveness of direct anti-viral agents for hepatitis C virus infection and a combined intervention of syringe access and medication assisted therapy for opioid use disorders in an injection drug use population.
TLDR
When considering health sector costs alone, DAA alone was the most cost-effective intervention, however, with criminal justice system-related costs, D AA and MAT+ implemented together become the mostcost-effective interventions.
We know DAAs work, so now what? Simplifying models of care to enhance the hepatitis C cascade
TLDR
There is an urgent need to identify and implement existing simplified MoCs that speak to specific populations’ needs and distil the findings into recommendations for how stakeholders can simplify the path taken by chronically HCV‐infected individuals from testing to cure and subsequent care and monitoring.
Modeling Combination HCV Treatment and Prevention Strategies in a Network of People Who Inject Drugs in the USA.
TLDR
Scale up ofHCV TasP is the most effective strategy for micro-elimination of HCV, however, OAT scale-up may be synergistic toward achieving micro-Elimination goals when HCV prevalence exceeds 60% and whenHCV treatment coverage is 10 per 100 PWID per year or lower.
Telemedicine Improves HCV Elimination among Italian People Who Use Drugs: An Innovative Therapeutic Model to Increase the Adherence to Treatment into Addiction Care Centers Evaluated before and during the COVID-19 Pandemic
TLDR
A novel “patient-tailored” model-of-care for people who use drugs was described, adapted to the needs of the patient and monitored remotely by a hepatological specialist, in order to decentralize the point of care within the addiction center, demonstrating the model’s high effectiveness in the linkage to care, adherence, and response to antiviral therapy.
A review of network simulation models of hepatitis C virus and HIV among people who inject drugs.
Modeling Combination Hepatitis C Virus Treatment and Prevention Strategies in a Network of People Who Inject Drugs in the United States
TLDR
Modeling Combination Hepatitis C Virus Treatment and Prevention Strategies in a Network of People Who Inject Drugs in the United States shows clear trends in treatment and prevention strategies used for HIV/AIDS patients.
Non-Invasive Diagnosis of Liver Fibrosis in Chronic Hepatitis C using Mathematical Modeling and Simulation
TLDR
The numerical analysis and simulation results indicate that the earlier the HCV treatment is implemented, the larger the group of people who will become responders, and less people will develop complications such as fibrosis.
Availability, Accessibility, and Coverage of Needle and Syringe Programs in Prisons in the European Union: A Multi-Stage Scoping Review.
TLDR
Despite the protective impact of the prison-based NSP on infection transmission, only four EU countries distribute sterile syringes among people who inject drugs in prisons, and coverage of the program within these countries is very low.
HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood–brain barrier integrity
TLDR
Investigations indicate that Tat and morphine differentially alter BBB integrity, and morphine decreased brain concentrations of specific antiretroviral drugs, perhaps via increased expression of the drug efflux transporter, P-glycoprotein.
The investigation of diabetes in people living with HIV: A systematic review
TLDR
The primary aim was to identify which tests are performed to diagnose and monitor diabetes in PLHIV and to identify whether prevalence or incidence of diabetes differs according to marker of glycaemia.
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