Combination gene therapy with adenoviral vector-mediated HSV-tk+GCV and IL-12 in an orthotopic mouse model for prostate cancer

@article{Nasu2001CombinationGT,
  title={Combination gene therapy with adenoviral vector-mediated HSV-tk+GCV and IL-12 in an orthotopic mouse model for prostate cancer},
  author={Yasutomo Nasu and C. Bangma and G W Hull and Guang Yang and Jianxiang Wang and Satoru Shimura and MA McCurdy and Shin Ebara and H M Lee and T L Timme and T C Thompson},
  journal={Prostate Cancer and Prostatic Diseases},
  year={2001},
  volume={4},
  pages={44-55}
}
We previously demonstrated significant therapeutic activities associated with adenoviral vector-mediated Herpes Simplex Virus/thymidine kinase (AdHSV-tk) with ganciclovir (GCV) in situ gene therapy in the RM-1 orthotopic mouse prostate cancer model and interleukin-12 (AdmIL-12) in situ gene therapy in the RM-9 orthotopic mouse prostate model for prostate cancer. In both protocols, local cytotoxicity and activities against pre-established lung metastases were demonstrated. To test whether… CONTINUE READING
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