Combination effects of baicalein with antibiotics against oral pathogens.

@article{Jang2014CombinationEO,
  title={Combination effects of baicalein with antibiotics against oral pathogens.},
  author={E. J. Jang and Sungman Cha and Sung-Mi Choi and Jeong-Dan Cha},
  journal={Archives of oral biology},
  year={2014},
  volume={59 11},
  pages={
          1233-41
        }
}

Figures and Tables from this paper

Synergistic Effect between Baicalein and Antibiotics against Clinic Methicillin and Vancomycin-Resistant Staphylococcus aureus
TLDR
The results suggest that baicalein could be employed as a natural antibacterial agent against multidrug-resistant pathogens infection.
Antimicrobial activity of the chloroform fraction of Drynaria fortunei against oral pathogens.
TLDR
DFCF exhibited the highest activity against the periodontic pathogens Prevotella intermedia and Porphylomonas gingivalis and in combination with ampicillin showed a strong synergistic effect against oral bacteria.
In vitro activity of five flavones from Scutellaria baicalensisin combination with Cefazolin against methicillin resistant Staphylococcus aureus (MRSA)
TLDR
It was found that these five flavones from Scutellaria baicalensis Georgi could strengthen the anti-Methicillin-resistant Staphylococcus aureus effect of cefazolin to varying degrees, and Baicalein and baicalin have stronger effect.
Antibacterial and synergistic effects of the n-BuOH fraction of Sophora flavescens root against oral bacteria.
TLDR
The present results suggest that n-BuOH and EtOAc extracts of S. flavescens root might be applicable as new natural antimicrobial agents against oral pathogens.
Synergistic effects of baicalein with cefotaxime against Klebsiella pneumoniae through inhibiting CTX-M-1 gene expression
TLDR
Baicalein exhibited synergistic activity when combined with cefotaxime against some of extended- spectrum β- lactamases positive K. pneumoniae strains by inhibiting CTX-M-1 mRNA expression, but no direct bactericidal or bacteriostatic activity was involved in the synergistic action.
Synergistic Antibacterial Effects of Nanoparticles Encapsulated with Scutellaria baicalensis and Pure Chlorhexidine on Oral Bacterial Biofilms
TLDR
Enhanced synergistic antibacterial effects of the Nano-MIX on common oral bacterial biofilms are shown, which could be potentially developed as a novel antimicrobial agent for clinical oral/periodontal care.
Phytochemicals: A Promising Weapon in the Arsenal against Antibiotic-Resistant Bacteria
TLDR
The present review summarizes the scientific evidence on the biochemical, pharmacological, and clinical aspects of phytochemicals used to treat microbial pathogenesis and suggests that phytomedicines are valuable sources of new types of antimicrobial agents for future use.
Antiprotozoal screening of the Cuban native plant Scutellaria havanensis
TLDR
Wogonin is an active principle compound of the chloroform extract of S. havanensis against P. berghei and T. vaginalis trophozoites, and the findings suggest that wog onin is potentially useful for the development of antimalarial alternative treatments.
Synergistic Antibacterial Activities of Bioactive Compounds from Streptomyces sp. RS2 in Combination with Vancomycin against Staphylococcus aureus
TLDR
The results demonstrate that the active compound exhibited synergistic interaction with S. aureus ATCC 25923, and the two active compounds will be studied particularly for the role or function of the two bioactive compounds in the future.
...
...

References

SHOWING 1-10 OF 44 REFERENCES
[Study on the inhibitory activity, in vitro, of baicalein and baicalin against skin fungi and bacteria].
TLDR
According to the antibacterial test of baicalein, a high efficacy was achieved against certain causative specie of axillary and foot's odour such as Micrococcus sedentarius, Staphylococcus epidermidis, S. hominis and C. xerosis with a MICs inferior to 250 micrograms/ml.
In vitro synergy of baicalein and gentamicin against vancomycin-resistant Enterococcus.
TLDR
It is demonstrated that baicalein and gentamicin can act synergistically in inhibiting VRE in vitro.
[Antibacterial activity and mechanism of baicalein].
TLDR
Baicalein had obvious antibacterial activity on Staphylococcus aureus, and the mechanism is that it could affect bacterial membrane penetrability, inhibit protein synthesis and influence SDH, MDH and DNA topoisomerase I and II activities to exert its antibacterial functions.
Remarkable Synergies between Baicalein and Tetracycline, and Baicalein and β‐Lactams against Methicillin‐Resistant Staphylococcus aureus
TLDR
Baicalein showed synergy with tetracycline in a MRSA strain that doesn't possess tetK, or with β‐lactams, and mechanisms of the synergies seem to be versatile.
In vitro synergistic effect of doxycycline & ofloxacin in combination with ethanolic leaf extract of Vangueria spinosa against four pathogenic bacteria.
TLDR
This study provides a preliminary report of synergistic activity of V. spinosa Roxb, ethanolic leaf extract with antibiotics and shows an additive effect for ofloxacin and plant extract combination.
Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria.
TLDR
The overall study emphasizes the potential of plant-derived molecules as a green and sustainable source of new broad spectrum antimicrobial products.
Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential.
TLDR
Compound 1 demonstrated significant antibacterial activity against three major periodontopathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, and Prevotella intermedia, and 2 exerted less pronounced effects on the above bacterial species.
Antimicrobial Activity and Phytochemical Constituents of Leaf Extracts of Cassia auriculata
TLDR
The antibacterial activity of Cassia auriculata extracts is possibly linked to the presence of flavonoids, steroid, saponins and/or tannins, and further studies are needed to determine the precise active principles.
Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses
TLDR
A combination of low-dose baicalein with other anti-influenza agents could be applicable for development of alternative remedies treating influenza A virus infection.
Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects
TLDR
The results of this study showed that baicalein scavenged intracellular ROS and protected cells via the inhibition of apoptosis induced by H2O2, suggesting that baicalsein provides protection for cellular components against oxidative damage via scavenging ROS and inhibiting apoptosis.
...
...