Corpus ID: 41363257

Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma.

@article{Grosios2000CombinationCW,
  title={Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma.},
  author={Konstantina Grosios and Paul M. Loadman and David J. Swaine and George R. Pettit and Michael C. Bibby},
  journal={Anticancer research},
  year={2000},
  volume={20 1A},
  pages={
          229-33
        }
}
The di-sodium phosphate pro-drug of combretastatin-A4(combA-4P) is undergoing Phase 1 clinical trial in the USA and UK. Its mechanism of action is thought to be related to tubulin-binding properties that result in rapid, tumour endothelial cell damage, neovascular shutdown and subsequent haemorrhagic necrosis. Drugs that work by this mechanism are unlikely to eradicate the tumour as a single agent but should potentiate standard chemotherapy. This study demonstrates that extensive necrosis… Expand
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Investigation of the effects of multiple daily or twice daily dosing with CA4P on the vascular function, cell survival and growth of syngeneic and spontaneous breast cancers in mice indicates that the potential anti‐tumour activity ofCA4P when used as a single agent in clinical trials may be enhanced when used in multiple dose schedules. Expand
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There was a dramatic therapeutic interaction between DMXAA and standard chemotherapy drugs, particularly paclitaxel, against the MDAH-MCa-4 tumour, which was not due to a pharmacokinetic interaction or potentiation of antivascular activity. Expand
The development of combretastatin A4 phosphate as a vascular targeting agent.
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  • Medicine
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Results confirm the ability of CA4P to selectively compromise vascular function in experimental tumors, inducing extensive tumor cell death at well-tolerated doses, and offer considerable potential for enhancing the effectiveness of existing and emerging cancer therapies. Expand
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This study of CA4P and carboplatin given in combination showed dose-limiting thrombocytopenia, and pharmacokinetic/pharmacodynamic modeling permitted the inference that alteredcarboplatin pharmacokinetics caused the increment in platelet toxicity. Expand
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It is shown that antibody-targeted radioimmunotherapy (RIT) effectively treated the well-perfused tumor rim, producing regressions for approximately 35 days, but was less effective at the more hypoxic center, and the need to consider cancer treatment in a biologically heterogeneous setting, if results are to be effectively translated to the clinic. Expand
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CA4DP significantly enhances the antitumour effect of CPT-11, which is not greatly influenced by the administration sequence, and which lacks a correlation with the intratumoral trapping of C PT-11 or SN-38. Expand
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