Combination chemotherapy of esophageal carcinoma using cisplatin, vindesine, and bleomycin.

Abstract

Sixty-one patients with epidermoid carcinoma of the esophagus have been treated with a three drug combination of cisplatin, vindesine, and bleomycin. Of 53 patients currently evaluable for response, 29 (55%) have had partial remissions: 7/16 with metastatic, and 22/37 with local-regional disease. The median duration of response in metastatic patients is eight months. Of 28 patients treated preoperatively, 23 (82%) had resectable disease. The major toxicities seen were nephrotoxicity and myelosuppression. Cisplatin, vindesine and bleomycin is an effective combination in the treatment of esophageal carcinoma. Effects on long-term survival cannot yet be evaluated.

Statistics

050100150'91'94'97'00'03'06'09'12'15
Citations per Year

114 Citations

Semantic Scholar estimates that this publication has 114 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Kelsen1982CombinationCO, title={Combination chemotherapy of esophageal carcinoma using cisplatin, vindesine, and bleomycin.}, author={David Paul Kelsen and Manjit S. Bains and Basil S. Hilaris and Robin A. Chapman and Patricia M E McCormack and J. -P. Alexander and S Hopfan and Nael Martini}, journal={Cancer}, year={1982}, volume={49 6}, pages={1174-7} }