Combination chemotherapy of esophageal carcinoma using cisplatin, vindesine, and bleomycin.


Sixty-one patients with epidermoid carcinoma of the esophagus have been treated with a three drug combination of cisplatin, vindesine, and bleomycin. Of 53 patients currently evaluable for response, 29 (55%) have had partial remissions: 7/16 with metastatic, and 22/37 with local-regional disease. The median duration of response in metastatic patients is eight months. Of 28 patients treated preoperatively, 23 (82%) had resectable disease. The major toxicities seen were nephrotoxicity and myelosuppression. Cisplatin, vindesine and bleomycin is an effective combination in the treatment of esophageal carcinoma. Effects on long-term survival cannot yet be evaluated.


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@article{Kelsen1982CombinationCO, title={Combination chemotherapy of esophageal carcinoma using cisplatin, vindesine, and bleomycin.}, author={David Paul Kelsen and Manjit S. Bains and Basil S. Hilaris and Robin A. Chapman and Patricia M E McCormack and J. -P. Alexander and S Hopfan and Nael Martini}, journal={Cancer}, year={1982}, volume={49 6}, pages={1174-7} }