Combination chemotherapy of adult acute lymphoblastic leukemia with randomized central nervous system prophylaxis.

@article{Omura1980CombinationCO,
  title={Combination chemotherapy of adult acute lymphoblastic leukemia with randomized central nervous system prophylaxis.},
  author={George A. Omura and Stephen Moffitt and William R. Vogler and Michael M Salter},
  journal={Blood},
  year={1980},
  volume={55 2},
  pages={199-204}
}
Although major progress has been made in the treatment of childhood leukemia, the optimal chemotherapy of acute lymphoblastic leukemia (ALL) in adults has been unclear. In addition, the value of central nervous system prophylaxis (CNS-P) in adults has been assumed, but not established in a systematic fashion. The Southeastern Cancer Study Group has completed a prospective study in which the use of vincristine plus low-dose methotrexate and high-dose prednisone in adult acute lymphoblastic… CONTINUE READING
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