Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis.

@article{Gelbard2006CombinationCA,
  title={Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis.},
  author={Alexander Gelbard and Charlie T. Garnett and Scott I Abrams and Vyomesh S. Patel and J. Silvio Gutkind and Claudia M Palena and K. Tsang and Jeffrey Schlom and James W Hodge},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 6},
  pages={1897-905}
}
PURPOSE The combination of systemic multiagent chemotherapy (5-fluorouracil + cisplatin) and tumor irradiation is standard of care for head and neck squamous cell carcinoma (HNSCC). Furthermore, it has been shown that sublethal doses of radiation or chemotherapeutic drugs in diverse cancer types may alter the phenotype or biology of neoplastic cells, making them more susceptible to CTL-mediated cytotoxicity. However, little is known about the potential synergistic effect of drug plus radiation… CONTINUE READING
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