Combination antimicrobial treatment versus monotherapy: the contribution of meta-analyses.

Abstract

Systematic reviews and meta-analyses have put into perspective the clinical implications of in vitro synergy (Box 1). Randomized, controlled trials are the cornerstone of evidence-based medicine. The trials included in the meta-analyses described in this article are the building blocks of evidence. Individual trials, however, were individually underpowered… (More)
DOI: 10.1016/j.idc.2009.01.004

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Cite this paper

@article{Paul2009CombinationAT, title={Combination antimicrobial treatment versus monotherapy: the contribution of meta-analyses.}, author={Mical Paul and Leonard Leibovici}, journal={Infectious disease clinics of North America}, year={2009}, volume={23 2}, pages={277-93} }