Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo

@inproceedings{Meng2010CombinationTW,
  title={Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo},
  author={Jieru Meng and Bingbing Dai and Bingliang Fang and Benjamin Nebiyou Bekele and William G. Bornmann and Duoli Sun and Zhenghong Peng and Roy S. Herbst and Vassiliki A. Papadimitrakopoulou and John D. Minna and Michael Peyton and J. L. A. Roth},
  booktitle={PloS one},
  year={2010}
}
AZD6244 and MK2206 are targeted small-molecule drugs that inhibit MEK and AKT respectively. The efficacy of this combination in lung cancer is unknown. Our previous work showed the importance of activated AKT in mediating resistance of non-small cell lung cancer (NSCLC) to AZD6244. Thus we hypothesized that dual inhibition of both downstream MEK and AKT pathways would induce synergistic antitumor activity. In this study, we evaluated the efficacy of AZD6244 and MK2206 individually on a large… CONTINUE READING
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