Combination Treatment With a Selective Androgen Receptor Modulator q(SARM) and a Bisphosphonate Has Additive Effects in Osteopenic Female Rats

@article{Vajda2009CombinationTW,
  title={Combination Treatment With a Selective Androgen Receptor Modulator q(SARM) and a Bisphosphonate Has Additive Effects in Osteopenic Female Rats},
  author={Eric G. Vajda and Aimee Hogue and Kimberly Griffiths and William Y. Chang and Kelven Burnett and Yanling Chen and Keith B. Marschke and Dale E. Mais and Bijan Pedram and Yixing Shen and Arjan van Oeveren and Lin Zhi and Francisco J. L{\'o}pez and Martin D. Meglasson},
  journal={Journal of Bone and Mineral Research},
  year={2009},
  volume={24}
}
Recent clinical trials with bisphosphonates and PTH have not supported the hypothesis that combination treatments with antiresorptive and anabolic agents would lead to synergistic activity. We hypothesized that combination treatment with a selective androgen receptor modulator (SARM), LGD‐3303, and a bisphosphonate would be beneficial. In vitro competitive binding and transcriptional activity assays were used to characterize LGD‐3303. LGD‐3303 is a potent nonsteroidal androgen that shows little… 

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