Combination Therapy with Metolazone and Loop Diuretics in Outpatients with Refractory Heart Failure: An Observational Study and Review of the Literature

@article{Rosenberg2005CombinationTW,
  title={Combination Therapy with Metolazone and Loop Diuretics in Outpatients with Refractory Heart Failure: An Observational Study and Review of the Literature},
  author={Jens Rosenberg and Finn Gustafsson and S{\o}ren Galatius and Per Rossen Hildebrandt},
  journal={Cardiovascular Drugs and Therapy},
  year={2005},
  volume={19},
  pages={301-306}
}
SummaryMetolazone is a potent thiazide-like diuretic. It is recommended in severe congestive heart failure (HF). We conducted a review of the existing literature and found that the available information on the use of metolazone in HF is based on studies containing less than 250 patients in total. Nevertheless, metolazone is widely used, often in combination with a loop diuretic. Absorption of metolazone seems to be reduced in HF. Metolazone produces a diuretic response despite a low glomerular… 

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