Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury

@inproceedings{Acosta2014CombinationTO,
  title={Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury},
  author={Sandra Antonieta Acosta and Naoki Tajiri and Kazutaka Shinozuka and Hiroto Ishikawa and Paul R. Sanberg and Juan Sanchez-Ramos and Shijie Song and Yuji Kaneko and Cesario V. Borlongan},
  booktitle={PloS one},
  year={2014}
}
Traumatic brain injury (TBI) is associated with neuro-inflammation, debilitating sensory-motor deficits, and learning and memory impairments. Cell-based therapies are currently being investigated in treating neurotrauma due to their ability to secrete neurotrophic factors and anti-inflammatory cytokines that can regulate the hostile milieu associated with chronic neuroinflammation found in TBI. In tandem, the stimulation and mobilization of endogenous stem/progenitor cells from the bone marrow… CONTINUE READING
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