Combination Immunotherapy for Type 1 Diabetes

@article{Bone2017CombinationIF,
  title={Combination Immunotherapy for Type 1 Diabetes},
  author={Robert N Bone and Carmella Evans-Molina},
  journal={Current Diabetes Reports},
  year={2017},
  volume={17},
  pages={1-12}
}
Purpose of ReviewType 1 diabetes (T1D) is an autoimmune disease marked by β-cell destruction. Immunotherapies for T1D have been investigated since the 1980s and have focused on restoration of tolerance, T cell or B cell inhibition, regulatory T cell (Treg) induction, suppression of innate immunity and inflammation, immune system reset, and islet transplantation. The purpose of this review is to provide an overview and lessons learned from single immunotherapy trials, describe recent and ongoing… CONTINUE READING
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