Combination Epigenetic Therapy

  title={Combination Epigenetic Therapy},
  author={Rūta Navakauskienė},
Abstract Epigenetic alterations caused by changes in DNA and histone modifications as well as microRNAs expression in turn cause variances in genes expression and cell phenotype. They have a great influence on the development of cancer and other diseases. The essential aim in developing novel epigenetic therapeutics is to understand the molecular mechanisms of abnormal DNA and posttranslational histone modifications implicated in tumor suppressors gene silencing or activation of oncogenes. The… CONTINUE READING