Combination Analysis of Activator Protein-1 FamilyMembers , Sp 1 and an Activator Protein-2 A-Related Factor Binding to Different Regions of the Urokinase Receptor Gene in Resected Colorectal Cancers

Purpose: Studies on the transactivation of genes via promoter elements have mostly been done on cell lines rather than resected tissues. This, however, is essential to address an in vivo or clinical relevance.We have previously shown tumor-specific binding of Sp1and an activator protein (AP)-2^ related factor to promoter region 152/ 135 of the metastasis… CONTINUE READING