Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

  title={Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers},
  author={Shu Jie Lam and Neil M. O’Brien-Simpson and Namfon Pantarat and Adrian Sulistio and Edgar H. H. Wong and Yu-Yen Chen and Jason C. Lenzo and James Austin Holden and Anton Blencowe and Eric C. Reynolds and Greg Guanghua Qiao},
  journal={Nature Microbiology},
With the recent emergence of reports on resistant Gram-negative ‘superbugs’, infections caused by multidrug-resistant (MDR) Gram-negative bacteria have been named as one of the most urgent global health threats due to the lack of effective and biocompatible drugs. [] Key Result Here, we show that a class of antimicrobial agents, termed ‘structurally nanoengineered antimicrobial peptide polymers’ (SNAPPs) exhibit sub-μM activity against all Gram-negative bacteria tested, including ESKAPE and colistin…
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