Combating enterovirus replication: state-of-the-art on antiviral research.

  title={Combating enterovirus replication: state-of-the-art on antiviral research.},
  author={Hendrik Jan Thibaut and Armando Mirko De Palma and Johan Neyts},
  journal={Biochemical pharmacology},
  volume={83 2},
Enteroviruses form an important genus within the large family of Picornaviridae. They are small, non-enveloped (+)RNA viruses, many of which are important pathogens in human and veterinary science. Despite their huge medical and socio-economical impact, there is still no approved antiviral therapy at hand for the treatment of these infections. Three capsid-targeting molecules (pleconaril, BTA-798 and V-073) are in clinical development. Pleconaril and BTA-798 are in phase II clinical trials for… CONTINUE READING


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Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307

  • AM De Palma, HJ Thibaut, L van der Linden, K Lanke, W Heggermont, S Ireland
  • Antimicrob Agents Chemother
  • 2009
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