Comatulins A-E, Taurine-Conjugated Anthraquinones from the Australian Crinoid Comatula rotalaria.

@article{Lum2020ComatulinsAT,
  title={Comatulins A-E, Taurine-Conjugated Anthraquinones from the Australian Crinoid Comatula rotalaria.},
  author={Kah Yean Lum and Aya C. Taki and Robin B. Gasser and Ian Tietjen and Merrick G Ekins and Jonathan M. White and Russell S. Addison and Sasha Hayes and James A. St John and Rohan A. Davis},
  journal={Journal of natural products},
  year={2020}
}
Chemical investigations of two specimens of the Australian crinoid Comatula rotalaria afforded five new taurine-conjugated anthraquinones, comatulins A-E (1-5), together with 11 known marine natural products (6-16). The chemical structures of all the compounds were elucidated by detailed spectroscopic and spectrometric data analysis. The first X-ray crystal structure of a crinoid-derived acyl anthraquinone, rhodocomatulin 5,7-dimethyl ether (8), is reported here. Compounds 1, 2, 6-13, and two… 
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Marine natural products.
Covering: 2020This review covers the literature published in 2020 for marine natural products (MNPs), with 757 citations (747 for the period January to December 2020) referring to compounds isolated

References

SHOWING 1-10 OF 15 REFERENCES
Rhodocomatulin-Type Anthraquinones from the Australian Marine Invertebrates Clathria hirsuta and Comatula rotalaria.
TLDR
This is the first report of the rhodocomatulin-type anthraquinones from a marine sponge, as 1 and 2 were previously isolated from the marine crinoid genus Comatula.
Hypalocrinins, Taurine-Conjugated Anthraquinone and Biaryl Pigments from the Deep Sea Crinoid Hypalocrinus naresianus.
TLDR
Five new water-soluble amido- and aminoanthraquinone pigments, hypalocrinins A-E, are the first naturally occurring anthraquinones and anthraquone biaryls conjugated with taurine.
Capillasterin A, a Novel Pyrano[2,3-f]chromene from the Australian Crinoid Capillaster multiradiatus
TLDR
This is the first report of a natural product that contains the pyrano[2,3-f]chromene skeleton and compounds 2–6 were observed to display moderate inhibition of in vitro HIV-1 replication in a T cell line with EC50 values ranging from 7.5 to 25.5 µM without concomitant cytotoxicity.
Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.
New quinone sulfates from the crinoids Tropiometra afra macrodiscus and Oxycomanthus japonicus.
Quinone pigments in the crinoids were investigated. New quinone sulfates 1 and 3 were isolated from Tropiometra afra macrodiscus and Oxycomanthus japonicus, respectively. The structures 1 and 3 were
NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus.
TLDR
Both naphthopyrones 1 and 2 completely inhibit TNF-alpha-induced NF-kappaB activation at a concentration of 300 microM by inhibiting the enzymatic activity of the kinase IKKbeta.
Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro
The gymnochromes: novel marine brominated phenanthroperylenequinone pigments from the stalked crinoid Gymnocrinus richeri
Five novel brominated phenanthroperylenequhone pigments, gymnochromes A-D (1-4) and isogymnochrome D (5), were isolated from the stalked crinoid Gymnocrinus richeri. The structures of the compounds
In vitro antiviral activity on dengue virus of marine natural products
TLDR
Only gymnochrome D and isogym nochrome D isolated from the living fossil crinoid Gymnocrinus richeri are highly potent dengue antiviral agents.
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