Coma in a patient with Alzheimer's disease taking low dose trazodone and gingko biloba.

@article{Galluzzi2000ComaIA,
  title={Coma in a patient with Alzheimer's disease taking low dose trazodone and gingko biloba.},
  author={Samantha Galluzzi and Orazio Zanetti and Giuliano Gb. Binetti and Marco Trabucchi and Giovanni B. Frisoni},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2000},
  volume={68 5},
  pages={
          679-80
        }
}
We describe a patient with Alzheimer's disease who developed coma a few days after starting low dose trazodone associated with ginkgo biloba. Coma was reversed by flumazenil, a specific antagonist of the benzodiazepine (BDZ) receptor. The finding is relevant in that, although the sedative effects of trazodone are well known, the drug is inactive on the BDZ receptor. On the other hand, ginkgo is active on the receptor, but sedation has so far never been reported. Pathway from trazodone to… CONTINUE READING

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