Column-switching HPLC for the analysis of plasma in PET imaging studies.

@article{Hilton2000ColumnswitchingHF,
  title={Column-switching HPLC for the analysis of plasma in PET imaging studies.},
  author={John Hilton and Fuji Yokoi and Robert F. Dannals and Hayden T. Ravert and Zolt{\'a}n Szab{\'o} and Dean F. Wong},
  journal={Nuclear medicine and biology},
  year={2000},
  volume={27 6},
  pages={
          627-30
        }
}
A column-switch high performance liquid chromatography method for the analysis of 4 mL of plasma is described with six examples of chromatography of [(11)C]-labeled positron-emission tomography imaging agents. Complete extraction of all but the most polar metabolites by the reverse phase capture column is achieved by disruption of plasma protein binding by 8 M urea. 
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