Colorimetric method for determining MICs of antimicrobial agents for Mycobacterium tuberculosis.

@article{Yajko1995ColorimetricMF,
  title={Colorimetric method for determining MICs of antimicrobial agents for Mycobacterium tuberculosis.},
  author={D. M. Yajko and J{\'o}zef Madej and M. V. Lancaster and Cynthia A. Sanders and V L Cawthon and Brian Gee and A F Babst and William Hadley},
  journal={Journal of clinical microbiology},
  year={1995},
  volume={33 9},
  pages={
          2324-7
        }
}
A colorimetric method for quantitative measurement of the susceptibility of Mycobacterium tuberculosis to antimicrobial agents is described. The method utilizes an oxidation-reduction dye, Alamar blue, as an indicator of growth. By this method, MICs of isoniazid, rifampin, streptomycin, and ethambutol were determined for 50 strains of M. tuberculosis. Colorimetric MIC results were available on the 7th, 10th, or 14th day of incubation for 29 (58%), 14 (28%), and 7 (14%) of the 50 strains… CONTINUE READING
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