Colored Petri net modeling and simulation of signal transduction pathways.

  title={Colored Petri net modeling and simulation of signal transduction pathways.},
  author={Dong-Yup Lee and Ralf Zimmer and Sang Yup Lee and Sunwon Park},
  journal={Metabolic engineering},
  volume={8 2},
Presented herein is a methodology for quantitatively analyzing the complex signaling network by resorting to colored Petri nets (CPN). The mathematical as well as Petri net models for two basic reaction types were established, followed by the extension to a large signal transduction system stimulated by epidermal growth factor (EGF) in an application study. The CPN models based on the Petri net representation and the conservation and kinetic equations were used to examine the dynamic behavior… CONTINUE READING
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