Colorectal carcinoma: from tumorigenesis to treatment

  title={Colorectal carcinoma: from tumorigenesis to treatment},
  author={Wei Wang and P. M. Chen and Yuliang Su},
  journal={Cellular and Molecular Life Sciences CMLS},
Colorectal carcinoma (CRC) is a complicated and often fatal genetic disease. Fortunately, owing to rapid expansion of knowledge and technology development in oncology, much progress has been made regarding the diagnosis, understanding of the molecular genetics and malignant progression, as well as the novel regimens of CRC. In this review, we summarize the staging system, the most critical genetic and epigenetic alterations, the pleiotropic effects of MMP-7, the controversial roles of Hedgehog… CONTINUE READING


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