Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunity.

Abstract

Intestinal microbiota are considered to play an important role both in colorectal tumor development and in the modulation of mucosal immunity. Studies on animals reared in germ-free (GF, without intestinal microbiota) versus conventional (CV, with regular microbiota colonization of the bowel) conditions can aid in clarifying the influence of bacteria on… (More)

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