Colorectal carcinogenesis: road maps to cancer.

@article{Worthley2007ColorectalCR,
  title={Colorectal carcinogenesis: road maps to cancer.},
  author={Daniel L. Worthley and Vicki-L Whitehall and Kevin-J Spring and B Leggett},
  journal={World journal of gastroenterology},
  year={2007},
  volume={13 28},
  pages={3784-91}
}
This review explores the chief genetic and epigenetic events that promote pathological progression in colorectal carcinogenesis. This article discusses the molecular and pathological basis for classifying colorectal neoplasia into suppressor, mutator and methylator pathways. These differing mechanisms of genomic instability are associated with specific cancer characteristics, and may provide the opportunity for more effective prevention and surveillance strategies in the future. This is the… CONTINUE READING

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