Colorectal cancer stem cells.

Abstract

Somatic stem cells reside at the base of the crypts throughout the colonic mucosa. These cells are essential for the normal regeneration of the colonic epithelium. The stem cells reside within a special 'niche' comprised of intestinal sub-epithelial myofibroblasts that tightly control their function. It has been postulated that mutations within these adult… (More)
DOI: 10.1111/j.1445-2197.2009.05054.x

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