Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity.

@article{Gomez2010ColorectalCC,
  title={Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity.},
  author={Alvin Gomez and Jana Nekvindov{\'a} and Sandra Travica and Mi-Young Lee and Inger Johansson and David Edler and Souren Mkrtchian and Magnus Ingelman-Sundberg},
  journal={Molecular pharmacology},
  year={2010},
  volume={78 6},
  pages={1004-11}
}
Cytochrome P450 2W1 (CYP2W1) is expressed at high levels in colorectal cancer cells. Moreover, we have shown previously that a higher tumor expression is associated with less survival. In this study, we characterize post-translational modification, inverted endoplasmic reticulum (ER) topology, and catalytic activity of CYP2W1. The analysis of colorectal normal and cancer tissues and CYP2W1 overexpressing human embryonic kidney (HEK) 293 cells showed that a fraction of CYP2W1 is modified by N… CONTINUE READING