Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes.

@article{Kiss2000ColorectalCR,
  title={Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes.},
  author={Istv{\'a}n Kiss and J{\'a}nos S{\'a}ndor and G{\'a}bor Pajkos and Barna Bogner and G{\'e}za Heged{\"u}s and Istvan A Ember},
  journal={Anticancer research},
  year={2000},
  volume={20 1B},
  pages={519-22}
}
Chemical carcinogens generally require metabolic activation in order to be able to bind to DNA and contribute to cancer causation. Most of the human metabolizing enzymes are genetically polymorphic, and these polymorphisms may affect the enzyme activity or inducibility. In our present study we investigated the connection between genetic polymorphism of cytochrome P450 1A1, 2E1 (phase I enzymes) and glutathione-S-transferase M1 (a phase II enzyme) and colorectal cancer occurrence in a Hungarian… CONTINUE READING