Colorectal cancer in review: the role of the EGFR pathway.

  title={Colorectal cancer in review: the role of the EGFR pathway.},
  author={Muhammad Wasif Saif},
  journal={Expert opinion on investigational drugs},
  volume={19 3},
IMPORTANCE OF THE FIELD The overexpression of EGFR has been documented in 30-90% of cases of advanced colorectal cancer (CRC). An increased understanding of the EGFR pathway in CRC has paved the way for the development of other targeted agents to augment therapeutic efficacy as well as for efforts to circumvent tumor resistance to therapy. AREAS COVERED IN THIS REVIEW Our aim is to discuss the recent progress in the role of the EGFR pathway, the status of anti-EGFR therapeutic agents… CONTINUE READING