Colorectal cancer cells with the BRAFV600E mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM

@article{Wickenden2008ColorectalCC,
  title={Colorectal cancer cells with the BRAFV600E mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM},
  author={Julie A Wickenden and H Jin and Michael Johnson and Annette S Gillings and Catherine Newson and Mark Austin and Simon D Chell and Kathryn Balmanno and Catrin A. Pritchard and Simon J Cook},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={7150-7161}
}
The RAF–mitogen-activated protein kinase kinase 1/2–extracellular signal-regulated kinase 1/2 (RAF–MEK1/2–ERK1/2) pathway is activated in many human tumours and can protect cells against growth factor deprivation; however, most such studies have relied upon overexpression of RAF or MEK constructs that are not found in tumours. Here we show that expression of the endogenous BRAFV600E allele in mouse embryonic fibroblasts from conditional knock-in transgenic mice activates ERK1/2, represses the… CONTINUE READING