Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1

  title={Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1},
  author={K. Lipiński and C. Britschgi and K. Schrader and Yann Christinat and Lukas Frischknecht and W. Krek},
  pages={29635 - 29647}
Chaperone dependency of cancer cells is an emerging trait that relates to the need of transformed cells to cope with the various stresses associated with the malignant state. URI1 (unconventional prefoldin RPB5 interactor 1) encodes a member of the prefoldin (PFD) family of molecular chaperones that acts as part of a heterohexameric PFD complex, the URI1 complex (URI1C), to promote assembly of multiprotein complexes involved in cell signaling and transcription processes. Here, we report that… Expand
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