Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption.

@article{Siezen2005ColorectalAR,
  title={Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption.},
  author={Christine L E Siezen and Astrid I M van Leeuwen and Nicolien R Kram and Manon E M Luken and Henk J van Kranen and Ellen Kampman},
  journal={Carcinogenesis},
  year={2005},
  volume={26 2},
  pages={449-57}
}
Associations between polymorphisms in genes (SNPs) involved in the arachidonic acid (AA) pathway and colorectal adenomas have been investigated in a Dutch case control study including 384 cases and 403 polyp-free controls. Twenty-one polymorphisms in seven candidate genes were studied and a potential modifying effect of fish consumption was considered. A protective effect on colorectal adenomas was found for the CT genotype of SNP H477H in PPARgamma and the GC genotype of SNP V102V in COX-2 (OR… CONTINUE READING