Colorectal Carcinogenesis: Connecting K-RAS-Induced Transformation and CREB Activity In Vitro and In Vivo.

@article{Steven2015ColorectalCC,
  title={Colorectal Carcinogenesis: Connecting K-RAS-Induced Transformation and CREB Activity In Vitro and In Vivo.},
  author={Andr{\'e} Steven and Max Heiduk and Christian V. Recktenwald and Bernhard Hiebl and Claudia Wickenhauser and Chiara Massa and Barbara Seliger},
  journal={Molecular cancer research : MCR},
  year={2015},
  volume={13 8},
  pages={1248-62}
}
UNLABELLED Oncogenic transformation is often associated with an increased expression of the cAMP response element binding (CREB) transcription factor controlling the expression of genes involved in cell proliferation, cell cycle, apoptosis, and tumor development, but a link between K-RAS(V12)-induced transformation and CREB has not yet been determined. Therefore, the constitutive and/or inhibitor-regulated mRNA and protein expression of CREB and signal transduction components and growth… CONTINUE READING

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