Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway

@inproceedings{Datta2016ColorectalCR,
  title={Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway},
  author={Kamal Datta and Shubhankar Suman and S. B. Vinay Kumar and Albert J. Fornace},
  booktitle={Journal of Cancer},
  year={2016}
}
Adult colorectal epithelium undergoes continuous renewal and maintains homeostatic balance through regulated cellular proliferation, differentiation, and migration. The canonical Wnt signaling pathway involving the transcriptional co-activator β-catenin is important for colorectal development and normal epithelial maintenance, and deregulated Wnt/β-catenin signaling has been implicated in colorectal carcinogenesis. Colorectal carcinogenesis has been linked to radiation exposure, and radiation… CONTINUE READING

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