Color-Coded Super-Resolution Small-Molecule Imaging.


Although the development of super-resolution microscopy dates back to 1994, its applications have been primarily focused on visualizing cellular structures and targets, including proteins, DNA and sugars. We now report on a system that allows both monitoring of the localization of exogenous small molecules in live cells at low resolution and subsequent super-resolution imaging by using stochastic optical reconstruction microscopy (STORM) on fixed cells. This represents a powerful new tool to understand the dynamics of subcellular trafficking associated with the mode and mechanism of action of exogenous small molecules.

DOI: 10.1002/cbic.201600013

Cite this paper

@article{Beuzer2016ColorCodedSS, title={Color-Coded Super-Resolution Small-Molecule Imaging.}, author={Paolo Beuzer and James J La Clair and Hu Cang}, journal={Chembiochem : a European journal of chemical biology}, year={2016}, volume={17 11}, pages={999-1003} }