Colony-stimulating factor-1 injections improve but do not cure skeletal sclerosis in osteopetrotic (op) mice.

@article{Sundquist1995ColonystimulatingFI,
  title={Colony-stimulating factor-1 injections improve but do not cure skeletal sclerosis in osteopetrotic (op) mice.},
  author={K. T. Sundquist and Marco Antonio G Cecchini and Sandy C. Marks},
  journal={Bone},
  year={1995},
  volume={16 1},
  pages={39}
}
The osteopetrotic (op) mutation in mice is characterized by general skeletal sclerosis; reduced numbers of osteoclasts, macrophages, and monocytes; and failure to be cured by bone marrow transplantation. This mutation has been shown to result from an absence of colony-stimulating factor-1 (CSF-1) and reported to be cured by treatment with CSF-1. Contrary to… CONTINUE READING