Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts.

@article{Novak1995ColonystimulatingF1,
  title={Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts.},
  author={Ulrike Novak and Ailsa G. Harpur and Lucy Paradiso and Varuni Kanagasundaram and Anthony Jaworowski and Andrew F. Wilks and John A Hamilton},
  journal={Blood},
  year={1995},
  volume={86 8},
  pages={2948-56}
}
Colony-stimulating factor 1 (CSF-1) causes the activation of STAT1 and STAT3 transcription factors in bone marrow macrophages (BMM), in the macrophage cell line BAC1.2F5, and in fibroblasts that express the wild-type receptor for CSF-1. Fibroblasts expressing a mutant receptor in which the tyrosine 809 is replaced with phenylalanine do not activate STAT proteins in response to CSF-1. The activation of the STAT proteins in BMM is accompanied by tyrosine phosphorylation of Tyk2. In fibroblasts… CONTINUE READING

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