Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1.

@article{Bouyer2007ColonystimulatingFI,
  title={Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1.},
  author={Patrice Bouyer and Hiroaki Sakai and Takashi Itokawa and Tsutomu Kawano and Christiaan M. Fulton and Walter F. Boron and Karl L. Insogna},
  journal={Endocrinology},
  year={2007},
  volume={148 2},
  pages={831-40}
}
Colony-stimulating factor-1 (CSF-1) promotes the survival of osteoclasts, short-lived cells that resorb bone. Although a rise in intracellular pH (pH(i)) has been linked to inhibition of apoptosis, the effect of CSF-1 on pH(i) in osteoclasts has not been reported. The present study shows that, in the absence of CO(2)/HCO(3)(-), CSF-1 causes little change in… CONTINUE READING