Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts.

  title={Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts.},
  author={Patrick Paulus and E Richard Stanley and Romana Sch{\"a}fer and Dietmar Abraham and Seyedhossein Aharinejad},
  journal={Cancer research},
  volume={66 8},
Overexpression of colony-stimulating factor-1 (CSF-1) and its receptor in breast cancer is correlated with poor prognosis. Based on the hypothesis that blockade of CSF-1 would be beneficial in breast cancer treatment, we developed a murinized, polyethylene glycol-linked antigen-binding fragment (Fab) against mouse (host) CSF-1 (anti-CSF-1 Fab). Mice bearing human, chemoresistant MCF-7 breast cancer xenografts were treated with combination chemotherapy (CMF: cyclophosphamide, methotrexate, 5… CONTINUE READING
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