Colonization of intestinal microbiota with carbapenemase-producing Enterobacteriaceae in paediatric intensive care units in Cairo, Egypt.

  title={Colonization of intestinal microbiota with carbapenemase-producing Enterobacteriaceae in paediatric intensive care units in Cairo, Egypt.},
  author={Doaa Mohammad Ghaith and Zeinat Kamel Mohamed and Mohamed G. Farahat and Walaa Aboulkasem Shahin and H. O. Mohamed},
  journal={Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology},
  volume={20 1},
  • D. GhaithZ. K. Mohamed H. O. Mohamed
  • Published 4 February 2019
  • Medicine, Biology
  • Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

Detection of intestinal colonization by carbapenem-resistant Enterobacteriaceae (CRE) among patients admitted to a tertiary care hospital in Egypt

The findings confirm that CRE colonization is disseminating in the authors' healthcare facility, a fact that should be considered as possible pathogens causing infections in high risk patients.

Genetic Relatedness of NDM-Producing Klebsiella pneumoniae Co-occurring VIM, KPC, and OXA-48 Enzymes from Surveillance Cultures from an Intensive Care Unit.

Molecular epidemiology data based on MLST revealed 11 different STs, 8 of which were novel and 3 were previously described, six out of the eight new STs were associated with MDR and PDR strains and two clonal complexes were reported, including CC258 and CC15.

In vitro antibacterial effect of probiotics against Carbapenamase-producing multidrug-resistant Klebsiella pneumoniae clinical isolates, Cairo, Egypt

The antimicrobial efficiency of using CFS of Lactobacillus species separately indicates that these therapies may be a substitute treatment strategy against MDR Klebsiella pneumoniae.

A Recombinase Aided Amplification Assay for Rapid Detection of the Klebsiella pneumoniae Carbapenemase Gene and Its Characteristics in Klebsiella pneumoniae

An easy and rapid recombinase aided amplification assay (RAA) for blaKPC was established and could be used for clinical diagnosis and epidemiological investigation.

Prevalence and incidence of carbapenem-resistant K. pneumoniae colonization: systematic review and meta-analysis

The review revealed that colonization with K. pneumoniae is higher in a healthcare setting with variable distribution in different localities, and resistance genes for carbapenem drugs also have unstable distributed in different geographic areas.

Epidemiology of carbapenemase-producing Enterobacterales in the Middle East: a systematic review

The health care system actors should take in a count the endemicity of CPE in these countries and develop local surveillance programs to limit the spread of these MDR bacteria.

Biochemical and Molecular Characterization of Klebsiella species isolated from neoplastic patients under Irradiation therapy

The emergence of widespread antibiotic-resistant bacteria enhanced the need for new sources of antimicrobial agents, and isolate SHM4-1 was active against all of them, and was genotypically identified as a species with the PKS 4 biosynthetic gene cluster present.

Klebsiella oxytoca Complex: Update on Taxonomy, Antimicrobial Resistance, and Virulence

The K. oxytoca complex is a human commensal but also an opportunistic pathogen causing various infections, such as antibiotic-associated hemorrhagic colitis, urinary tract infection, and bacteremia, and has caused outbreaks.



High rate of faecal carriage of extended-spectrum β-lactamase and OXA-48 carbapenemase-producing Enterobacteriaceae at a university hospital in Morocco.

The high prevalence of multidrug-resistant Enterobacteriaceae is shown, and particularly of OXA-48 producers, and the new carbapenem-containing medium, SUPERCARBA, was as sensitive as Brilliance CRE and ChromID ESBL, and more specific for the detection of Enterobacteriaiaceae expressing those carbAPenemases.

The emergence of OXA-48- and NDM-1-positive Klebsiella pneumoniae in Riyadh, Saudi Arabia.

First reported nosocomial outbreak of Serratia marcescens harboring blaIMP-4 and blaVIM-2 in a neonatal intensive care unit in Cairo, Egypt

For the first time, the detection of MBL-producing S. marcescens isolates, particularly IMP-4 and VIM-2 recovered from inpatients with bacteremias from the intensive care unit at Cairo University Hospital is reported.

Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities.

Infection with carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae is emerging as an important challenge in health-care settings. Currently,

Predictors of Carbapenem-Resistant Klebsiella pneumoniae Acquisition among Hospitalized Adults and Effect of Acquisition on Mortality

CRKP affects patients with poor functional status, an ICU stay, and antibiotic exposure and is an independent predictor of death.

Predictors of Rectal Carriage of Carbapenem-Resistant Enterobacteriaceae (CRE) among Patients with Known CRE Carriage at Their Next Hospital Encounter

Prior fluoroquinolone use, transfer from another healthcare facility, and admission less than or equal to 3 months since the first CRE isolation are predictors of persistent CRE rectal carriage.

The spread of carbapenemase-producing bacteria in Africa: a systematic review.

Antibiotic stewardship and surveillance systems, including molecular detection and genotyping of resistant isolates, should be implemented to monitor and reduce the spread of carbapenemase-producing bacteria.

Prevalence of extensively drug-resistant gram negative bacilli in surgical intensive care in Egypt

Extensively drug-resistant gram negative infections are frequent in the surgical intensive care unit, Cairo university teaching hospital, which emphasizes the need to rigorously implement infection control practices.