Colonisation and infection of the paranasal sinuses in cystic fibrosis patients is accompanied by a reduced PMN response.

@article{Johansen2012ColonisationAI,
  title={Colonisation and infection of the paranasal sinuses in cystic fibrosis patients is accompanied by a reduced PMN response.},
  author={Helle Krogh Johansen and Kasper Aanaes and Tania Pressler and Kim Gjerrum Nielsen and Jacob Lund Fisker and Marianne Nielsine Skov and Niels H\oiby and Christian von Buchwald},
  journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society},
  year={2012},
  volume={11 6},
  pages={525-31}
}
BACKGROUND We studied whether the sinuses might be foci for Pseudomonas aeruginosa lung infection. METHODS Endoscopic Sinus Surgery was performed in 78 CF patients; PFGE was used for bacterial genotyping. Material from sinuses and lungs were Gram-stained to detect biofilms. Immunoglobulins were measured in serum and saliva. RESULTS When P. aeruginosa was cultured simultaneously from the sinuses and the lungs they were genetically identical in 38 of the 40 patients (95%). In the sinuses, P… CONTINUE READING
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